This collection consists of the minutes of annual meetings (called a District Conference) by the Opelousas District of the Louisiana Conference of the Methodist Episcopal Church South. These meetings were attended by the district’s clergy and lay delegates from each pastoral charge; it was presided over by the district's presiding elder.

The minutes document the administrative activities of the meetings and regularly include the following reports: religious and financial state of churches, Sunday School work, missions, and denominational education and literature, and Woman’s Missionary Societies.